GW 610

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

GW 610 是一种抗肿瘤苯并噻唑，对多种癌细胞系显示出生长抑制活性。

GW 610 is an antitumor benzothiazole that shows growth-inhibitory activity against several cancer cell lines. In MCF-7 and MDA 468 human cancer cell lines, potent antiproliferative activity (growth inhibition (GI50) < 0.1 nM) was observed.

GW 610 inhibits the proliferation of MCF-7, MDA?468, KM?12, and HCC?2998 cells, with GI50s of <0.1 nM, <0.1 nM, 290 nM, and 0.25 nM, respectively.GW 610 (0.1-1 μM) induces CYP1A1 mRNA and protein in MDA-MB-468, MCF-7, KM12, and HCC2998 cells, whereas CYP2S1 and CYP2W1 are induced only in breast cancer cells.Western Blot Analysis Cell Line:MDA-MB-468, MCF-7, KM12, and HCC2998 cells Concentration:0.1, 1 μM Incubation Time:48 hours Result:Induced CYP1A1 mRNA and protein in all cell lines including KM12 and HCC2998 CRC cells.Induced CYP2S1 and CYP2W1 mRNA and protein expression in MDA-MB-468 and MCF-7 breast cancer cells.

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Others

Other Targets

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872726-44-8

289.33

C15H12FNO2S

>98% (HPLC)

In Vitro:?DMSO : 25 mg/mL (86.41 mM)

COc(ccc(-c1nc(cc(cc2)F)c2s1)c1)c1OC

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(-20℃)

With Ice Pack

≥ 2 years